Dynamic and selective engrams emerge with memory consolidation | Nature Neuroscience

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Nature Neuroscience volume  27,  pages 561–572 (2024)Cite this article 15k Accesses 146 Altmetric Metrics details Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this study, we employed computational and experimental approaches to examine how the neural composition and selectivity of engrams change with memory consolidation. Our spiking neural network model yielded testable predictions: memories transition from unselective to selective as neurons dr

Main A growing body of evidence has shown that neurons activated by an experience have a prominent role in memory1,2. Specifically, loss-of-function and gain-of-function studies have demonstrated that ablating neurons activated during learning disrupts memory retrieval3, whereas artificially reactivating these neurons elicits memory recall even in the absence of retrieval cues4. Therefore, learning-activated neurons are a cellular substrate for memory storage and retrieval, and they constitute engram cells. The stability of engrams after memory encoding, however, remains an open question.…

saved by

• Jennifer Tsai

related reading

• Engram neurons: Encoding, consolidation, retrieval, and forgetting of memorynature.com
• Complementary task representations in hippocampus and prefrontal cortex for generalizing the structure of problemsnature.com
• Precise coupling of the thalamic head-direction system to hippocampal ripplesnature.com
• Molecular Mechanisms of the Memory Tracencbi.nlm.nih.gov
• Engram (neuropsychology) - Wikipediaen.wikipedia.org
• Memory formation in the absence of experiencenature.com
• Hopfield network - Wikipediaen.wikipedia.org
• https://io0.github.ioio0.github.io
• Key-value memory in the brainarxiv.org
• The honeybee as a model for understanding the basis of cognitionbcp.fu-berlin.de
• Sleep microstructure organizes memory replay | Naturenature.com
• McKenzie Lab – Synchrony plasticity memorymckenzieneurolab.com