Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging | Neuropsychopharmacology
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Neuropsychopharmacology (2024)Cite this article Metrics details A central goal of neuroscience is to understand how the brain transforms external stimuli and internal bodily signals into patterns of activity that underlie cognition, emotional states, and behavior. Understanding how these patterns of activity may be disrupted in mental illness is crucial for developing novel therapeutics. It is well appreciated that psychiatric disorders are complex, circuit-based disorders that arise from dysfunctional activity patterns generated in discrete cell types and their connections. Recent advances in large-scale, ce
Xia F, Kheirbek MA. Circuit-based biomarkers for mood and anxiety disorders. Trends Neurosci. 2020;43:902–15. Article CAS PubMed PubMed Central Google Scholar Zhou ZC, Gordon-Fennell A, Piantadosi SC, Ji N, Smith SL, Bruchas MR, Stuber GD. Deep-brain optical recording of neural dynamics during behavior. Neuron. 2023;111:3716–38. Article CAS PubMed PubMed Central Google Scholar Bi X, Beck C, Gong Y. Genetically encoded fluorescent indicators for imaging brain chemistry. Biosensors. 2021;11:116. Article CAS PubMed PubMed Central Google Scholar Lin MZ, Schnitzer MJ. Genetically encoded…
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