Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory | Molecular Psychiatry
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Molecular Psychiatry volume 28, pages 3207–3219 (2023)Cite this article 9401 Accesses 2 Citations 11 Altmetric Metrics details Tremendous strides have been made in our understanding of the neurobiological substrates of memory – the so-called memory “engram”. Here, we integrate recent progress in the engram field to illustrate how engram neurons transform across the “lifespan” of a memory — from initial memory encoding, to consolidation and retrieval, and ultimately to forgetting. To do so, we first describe how cell-intrinsic properties shape the initial emergence of the engram at memory encoding. Second,
Tonegawa S, Liu X, Ramirez S, Redondo R. Memory engram cells have come of age. Neuron. 2015;87:918–31. Article CAS PubMed Google Scholar Tonegawa S, Morrissey MD, Kitamura T. The role of engram cells in the systems consolidation of memory. Nat Rev Neurosci. 2018;19:485–98. Article CAS PubMed Google Scholar Tonegawa S, Pignatelli M, Roy DS, Ryan TJ. Memory engram storage and retrieval. Curr Opin Neurobiol. 2015;35:101–9. Article CAS PubMed Google Scholar Vetere G, Tran LM, Moberg S, Steadman PE, Restivo L, Morrison FG, et al. Memory formation in the absence of experience. Nat…
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