Complementary task representations in hippocampus and prefrontal cortex for generalizing the structure of problems | Nature Neuroscience
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Nature Neuroscience volume 25, pages 1314–1326 (2022)Cite this article 19k Accesses 8 Citations 86 Altmetric Metrics details Humans and other animals effortlessly generalize prior knowledge to solve novel problems, by abstracting common structure and mapping it onto new sensorimotor specifics. To investigate how the brain achieves this, in this study, we trained mice on a series of reversal learning problems that shared the same structure but had different physical implementations. Performance improved across problems, indicating transfer of knowledge. Neurons in medial prefrontal cortex (mPFC) maintained
Main When we walk into a new restaurant, we know what to do. We might find a table and wait to be served. We know that the starter will come before the main, and when the bill arrives, we know it is the food we are paying for. This is possible because we already know a lot about how restaurants work and only have to map this knowledge onto the specifics of the new situation. This requires that the common structure is abstracted away from the sensorimotor specifics of experience, so it can be applied seamlessly to new but related situations. Such abstraction has been variously described as…
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