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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics | Nature Reviews Drug Discovery

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Karran, E., Mercken, M. & De Strooper, B. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics. Nat. Rev. Drug Discov. 10, 698–712 (2011). Article CAS PubMed Google Scholar Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 349, 704–706 (1991). Article CAS PubMed Google Scholar Sherrington, R. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease. Nature 375, 754–760 (1995). Article CAS PubMed Google Scholar…

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