APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease | Nature Medicine

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Nature Medicine volume 30, pages 1284–1291 (2024)Cite this article 43k Accesses 203 Citations 4638 Altmetric Metrics details Matters Arising to this article was published on 18 July 2024 A Publisher Correction to this article was published on 17 June 2024 This article has been updated This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer’s Coordinating Center and five large cohorts with A

Subjects Alzheimer's disease Dementia Predictive markers Matters Arising to this article was published on 18 July 2024 A Publisher Correction to this article was published on 17 June 2024 This article has been updated Abstract This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer’s Coordinating Center and five large cohorts with AD biomarkers were analyzed. The analysis inclu

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