Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients | Nature Biomedical Engineering
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Nature Biomedical Engineering volume 5, pages 219–228 (2021)Cite this article 14k Accesses 319 Citations 504 Altmetric Metrics details Changes in cerebral blood flow are associated with stroke, aneurysms, vascular cognitive impairment, neurodegenerative diseases and other pathologies. Brain angiograms, typically performed via computed tomography or magnetic resonance imaging, are limited to millimetre-scale resolution and are insensitive to blood-flow dynamics. Here we show that ultrafast ultrasound localization microscopy of intravenously injected microbubbles enables transcranial imaging of deep vasculat
References Liesz, A. The vascular side of Alzheimer’s disease. Science 365, 223–224 (2019). Article CAS Google Scholar O’Brien, J. T. & Thomas, A. Vascular dementia. Lancet 386, 1698–1706 (2015). Article Google Scholar Betzig, E. et al. Imaging intracellular fluorescent proteins at nanometer resolution. Science 313, 1642–1645 (2006). Article CAS Google Scholar Rust, M. J., Bates, M. & Zhuang, X. Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat. Methods 3, 793–796 (2006). Article CAS Google Scholar Errico, C. et al. Ultrafast ultrasound…
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