A body–brain circuit that regulates body inflammatory responses | Nature
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Nature (2024)Cite this article 2970 Accesses 1 Citations 274 Altmetric Metrics details We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply. The body-brain axis is emerging as a principal conductor of organismal physiology. It senses and controls organ function1,2, metabolism3 and nutritional state4-6. Here, we show that a peripheral immune insult powerfully activates the body-brain axis to regulate imm
Main A well-balanced immune response is of fundamental importance for the fitness and survival of the organism. An overactive pro-inflammatory state invariably leads to immune dysregulation, including a diverse range of autoimmune and inflammatory diseases7,8. Understanding the mechanisms that tune the immune response may afford important insights into the function of the immune system, and provide novel strategies to combat disorders and diseases characterized by dysregulated immune states. Much is known about innate9 and adaptive immunity10, with numerous cellular and humoral factors…
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