Brillouin microscopy: an emerging tool for mechanobiology | Nature Methods

This Review discusses the principles, advantages and limitations of Brillouin microscopy, a non-invasive tool for measuring mechanical properties of biological samples in three dimensions.

References Petridou, N. I., Spiró, Z. & Heisenberg, C.-P. Multiscale force sensing in development. Nat. Cell Biol. 19, 581–588 (2017). CAS PubMed Google Scholar van Helvert, S., Storm, C. & Friedl, P. Mechanoreciprocity in cell migration. Nat. Cell Biol. 20, 8–20 (2018). PubMed Google Scholar Mathieu, S. & Manneville, J.-B. Intracellular mechanics: connecting rheology and mechanotransduction. Curr. Opin. Cell Biol. 56, 34–44 (2019). CAS PubMed Google Scholar Guck, J. et al. Optical deformability as an inherent cell marker for testing malignant transformation and metastatic…

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