Marley Xiong

on the atlas — 329

• Is the Internet Making Culture Worse?—Asterisk8 savers
• Speed matters: Why working quickly is more important than it seems « the jsomers.net blog66 savers
• Show your hands honor for the strange power they bring you – Aresluna5 savers
• There’s no speed limit56 savers
• Human Routers of Machine Words5 savers
• Becoming a magician – Autotranslucence40 savers
• Questions · Patrick Collison25 savers
• Standing Invitation | Kalzumeus Software7 savers
• Resources for definite optimism9 savers
• Kartik Chandra2 savers
• I Moved Back to a Second-Tier City and Finally Started Living22 savers
• YouTube21 savers
• Don't Call Yourself A Programmer, And Other Career Advice | Kalzumeus Software37 savers
• As We May Think26 savers
• Deliverance From 27,000 Feet2 savers
• Theory of Change (Aaron Swartz's Raw Thought)83 savers
• Michael Levin: The electrical blueprints that orchestrate life | TED - YouTube24 savers
• Hot-air-balloon-Paris_1914.jpg (880×1208)1 savers
• File:Moonrise, Hernandez, New Mexico (cropped).jpg1 savers
• File:Edward_Weston,_Armco_Steel,_Ohio,_1922,_MoMA.jpg1 savers
• File:A_Sea_Of_Steps_--_Wells_Cathedral_LACMA_M.2008.40.736_(1_of_3).jpg1 savers
• How To Be Successful96 savers
• Cargo Cult Science14 savers
• What 81,000 people want from AI \ Anthropic26 savers
• Okapi BM254 savers
• A Phonemic-Based Tactile Display for Speech Communication | IEEE Journals & Magazine | IEEE Xplore1 savers
• Laws of UX13 savers
• Ultrafast Doppler Reveals the Mapping of Cerebral Vascular Resistivity in Neonates - Charlie Demené, Mathieu Pernot, Valérie Biran, Marianne Alison, Mathias Fink, Olivier Baud, Mickaël Tanter, 20141 savers
• Interact10 savers
• More Human Than Man - The Future Evolution and Consequences of Metacomputers - Outline, Proposal, and Excerpts.pdf3 savers
• The AI Sound House3 savers
• Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging | Nature1 savers
• A heart of fire21 savers
• In (highly contingent!) defense of interpretability-in-the-loop ML training — AI Alignment Forum4 savers
• Always bet on text7 savers
• advice16 savers
• How to Teach Stuff6 savers
• The Shigalyovist Turn16 savers
• Rekindling Is Refining4 savers
• Human brain hemodynamics for 3D ultrasound localization microscopy benchmarking - ScienceDirect1 savers
• OH no Type Company3 savers
• Goody_1963_-_The_Consequences_of_Literacy.pdf1 savers
• Peek Quotes1 savers
• I should have loved biology36 savers
• My path to OpenAI16 savers
• The making of OpenAI - Greg Brockman8 savers
• Longevity FAQ — Laura Deming13 savers
• Butterick’s Practical Typography21 savers
• Curius4 savers
• Gossip is Good13 savers
• Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale | Science1 savers
• Where do your eyes go? | Radimentary2 savers
• Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients | Nature Biomedical Engineering2 savers
• The Twenty-One Second God - Lightspeed Magazine3 savers
• Hand on my heart,7 savers
• Kaihang Wang - Biology and Biological Engineering1 savers
• Guessing the Teacher's Password12 savers
• How To Make (almost) Anything23 savers
• Towards Consciousness Engineering - YouTube3 savers
• Max Hodak - A Science corporation7 savers
• untitled1 savers
• Communicating with Interactive Articles6 savers
• Acoustic transparency and slow sound using detuned acoustic resonators - Astrophysics Data System1 savers
• How a Kalman filter works, in pictures | Bzarg3 savers
• Toward an exploratory medium for mathematics2 savers
• Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods1 savers
• blogroll | benkuhn.net16 savers
• AI 20278 savers
• What If We Had Bigger Brains? Imagining Minds beyond Ours—Stephen Wolfram Writings6 savers
• Beware The Man Of One Study | Slate Star Codex6 savers
• Beamforming_sebka.pptx2 savers
• The web browser as a tool of thought | thesephist.com9 savers
• To the brain, reading computer code is not the same as reading language2 savers
• How Did Solar Power Get Cheap? Part II - by Brian Potter3 savers
• Principles of Persistent Spectral Hole Burning - Dr. Aleks Rebane | Montana State University2 savers
• Introduction | Shape Up4 savers
• The Stamp Collector5 savers
• College as an incubator of Girardian terror | Dan Wang35 savers
• Why does DARPA work?16 savers
• Interesting Lab Websites | LoganThrasherCollins.com9 savers
• I could do that in a weekend!6 savers
• Status as a Service (StaaS) — Remains of the Day27 savers
• How I side project8 savers
• Why Figma Wins - kwokchain7 savers
• From Nand to Tetris: building a modern computer from first principles5 savers
• Interview with Ben Kuhn about productivity, his college experience, job choice, the value of an inside view, the EA community - Alexey Guzey7 savers
• Stop trying to try and try32 savers
• [1911.01547] On the Measure of Intelligence12 savers
• Understanding41 savers
• The Post-YC Slump - Sam Altman7 savers
• Stupid Apps and Changing the World8 savers
• Speed matters3 savers
• Failure Resume | Kat Huang7 savers
• The network for ambitious outsiders10 savers
• Take Asymmetric Bets8 savers
• Engineer by Day, Venture Capitalist by Night | by Casey Caruso | Medium11 savers
• Do Things that Don't Scale11 savers
• The Hardest Lessons for Startups to Learn5 savers
• Early Work5 savers
• The Feynman Lectures on Physics Vol. I Ch. 2: Basic Physics7 savers

highlights — 1547

• Because great art is, in many ways, the solution to the attention economy’s problems. Much of the internet is now optimized for shallow and trivially dopaminergic slop, but perhaps it’s also accentuated the unique value proposition, if you will, of genuine artistic works. Art can hold our attention in a more rewarding way — restoring the capacities that have been degraded by other apps.

  Is the Internet Making Culture Worse?—Asterisk

• In coronal planes and parasagittal planes, we image smaller vessels such as lenticulostriate arteries or cortical arteries where the blood flow is much slower (less than 10 cm/s) and a frame rate of 800 Hz is enough to correctly sample the data.

  Ultrafast Doppler Reveals the Mapping of Cerebral Vascular Resistivity in Neonates - Charlie Demené, Mathieu Pernot, Valérie Biran, Marianne Alison, Mathias Fink, Olivier Baud, Mickaël Tanter, 2014

• We added a linear spatial interpolation on each track to count one MB detection in every pixel on the MB path.

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• What Leo "Bob Marley" Tosltoy is saying here is that: music is love, man.

  The AI Sound House

• Second, since they respond to ultrasound differently over several frames, microbubbles blink separately through the spatiotemporal differentiation process and become temporally separable sources.

  Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging | Nature

• Directivity filters were made for each probe, in both transmit and receive, based on the angular aperture of the probe elements previously studied in Ref. [15]. These filters account for the number of contributing elements at each point of the volume.

  Human brain hemodynamics for 3D ultrasound localization microscopy benchmarking - ScienceDirect

• Beliefs and desires are stored in different parts of the brain, and updated in different ways.

  In (highly contingent!) defense of interpretability-in-the-loop ML training — AI Alignment Forum

• Only innocence can surmount them, which mere knowledge doesn't even take into account, in those moments when we find ourselves able to listen to things, totally and intensely absorbed in child's play.

  advice

• In our acquisition of knowledge of the Universe (whether mathematical or otherwise) that which renovates the quest is nothing more nor less than complete innocence. It is in this state of complete innocence that we receive everything from the moment of our birth. Although so often the object of our contempt and of our private fears, it is always in us. It alone can unite humility with boldness so as to allow us to penetrate to the heart of things, or allow things to enter us and taken possession of us.

  advice

• The coming generation of AI will complete the turn.

  The Shigalyovist Turn

• Dostoevsky knew better. Shigalyov knew better.

  The Shigalyovist Turn

• Most founders resist this. They want to preserve the culture of the garage, the feeling of unlimited possibility, the flat hierarchy, the sense that everyone is in on the mission.

  The Shigalyovist Turn

• To model transcranial energy loss, an attenuation of 10 dB was applied, corresponding to the double passage of ultrasound through 5 mm of skull bone [32]. The transmitted pressure amplitude was set to 1 MPa, and random noise was added with an equivalent pressure level of 100 Pa [33], as previously described in Ref. [15].

  Human brain hemodynamics for 3D ultrasound localization microscopy benchmarking - ScienceDirect

• 70 blocks of 1 s each consisted of 30 s rest, 30 s stimulation and 10 s rest repeated 20 times and summed

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• Instead, their members are faced with permanently recorded versions of the past and its beliefs; and because the past is thus set apart from the present, historical enquiry becomes possible. This in turn encourages scepticism; and scepticism, not only about the legendary past, but about received ideas about the universe as a whole. From here the next step is to see how to build up and to test alternative explanations: and out of this there arose the kind of logical, specialized, and cumulative intellectual tradition of sixth-century Ionia

  Goody_1963_-_The_Consequences_of_Literacy.pdf

• In typical 30-µm diameter arterioles, MBs per second are sufficient to provide dynamic fULM without repetition (in single trials). In 10-µm diameter vessels, the required repetitions number is typically n = 10, which remains reasonable for whole-brain imaging.

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• Consequently, ULM has not been able to visualize capillaries despite capillaries representing the largest vascular territory of living organisms

  Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale | Science

• However, quantification of the spatial resolution by resolving two nearest small vessels is not an adapted approach as it is very unlikely to track a sufficient number of microbubbles flowing in two extremely close microvessels in the 45-s acquisition time.

  Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients | Nature Biomedical Engineering

• Attenuation is of course also a factor but we can see in Fig. 2d that sensitivity is still good at 110 mm (vessels are visible), while the resolution is degraded (vessels are blurry)

  Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients | Nature Biomedical Engineering

• “Spawning cycle. Field test. How can we know? We’re earthworms, trying to divine the thoughts of astronauts.”

  The Twenty-One Second God - Lightspeed Magazine

• “You wanted to know how it made me feel. You have to know this before you can know that. Because once the arm is gone, everything just goes gray. You’re not connected to the universe; you’re not even really connected to your own body. You just—exist.

  The Twenty-One Second God - Lightspeed Magazine

• I try again. “You know how, when you close your eyes, you still know where all your parts are? You just know, without looking, where you end and everything else begins?” He nods. “Imagine that you knew, in the exact same way, that you went on forever. That everything else was as much a part of you as your arms and legs.”

  The Twenty-One Second God - Lightspeed Magazine

• In the meantime, someone snuck in through the back door. Someone disabled the lag and unleashed a globe-spanning corpus callosum that connected fifteen million brains as intimately as the hemispheres in one connect to each other. There was no we in those moments, any more than there are two people in my head right now. There was only the Twenty-One Second God. The rest is history.

  The Twenty-One Second God - Lightspeed Magazine

• Thanks to you I know that when you anesthetize half a brain, the other half might manifest a whole new personality. I know that when the drugs wear off, that short-lived persona—that standalone, autonomous being—gets swallowed back into the greater whole

  The Twenty-One Second God - Lightspeed Magazine

• Ask the pianist, mid-concerto, to think about what their fingers are doing. Ask the martial artist which muscles are moving in which order, why they feinted left instead of right. Once the knowledge has been assimilated, being aware of it only destroys the performance.

  The Twenty-One Second God - Lightspeed Magazine

• Of course, that’s hardly unusual; you always delighted in pointing out that most of our thoughts are unconscious even at the best of times.

  The Twenty-One Second God - Lightspeed Magazine

• Those assimilated later were never more than whispers in a hurricane: they remember as much as a single neuron might, if you ripped it from someone’s head and demanded to know what the brain was thinking.

  The Twenty-One Second God - Lightspeed Magazine

• Twenty-One Second God

  The Twenty-One Second God - Lightspeed Magazine

• If the voxel of interest is within an arteriole with typical 30–60-µm diameter, several MBs can be detected every second leading to a high SNR

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• The pulse shape corresponds to two periods of sinusoids, the transmit voltage is 5 V and the mechanical index is 0.09

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• Another ∼ 10 5 channels record the interferometer ’ s operating point and the state of the control systems

  untitled

• These systems collectively provide more than 10 orders of magnitude of isolation from ground motion for frequen- cies above 10 Hz.

  untitled

• which is further increased to 100 kW circulating in each arm cavity

  untitled

• The ensemble size was adaptively set to match one cardiac cycle.

  Frontiers | Functional Ultrasound (fUS) During Awake Brain Surgery: The Clinical Potential of Intra-Operative Functional and Vascular Brain Mapping

• Although 2D piezoelectric matrix array transducers are emerging for volumetric imaging, they are hampered by low individual element sensitivity compared to conventional one-dimensional linear probes, or by their integrated sequential pre-beamforming required to lower data transfer rate from the probe to the scanner.

  4D functional ultrasound imaging of whole-brain activity in rodents | Nature Methods

• 30 MBs per ultrasound frame

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• A magnet was inserted in the syringe to mix the MB solution during the acquisition.

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• We also show results for a 500-ms window, where there is a risk of losing sensitivity to the smallest blood vessels by diminishing the temporal step too much.

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• intraparenchymal vessels compared to larger vessels such as penetrating arterioles or pial arterioles

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• In a smaller vessel, for a typical pixel such as δ in Fig. 1e located within a first-order branch of a penetrating arteriole, the signal is sparse as the flow is too small to derive a MB detection probability >1 every 5 s; however, the detection of individual MBs occurs mainly during stimulation.

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• of MBs between 0 and 10 every 5 s, increasing during whisker stimulations.

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• MB flow, speed and vessel diameters

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• Yet, MB displacements are driven by cerebrovascular perfusion, resulting in long acquisition times for obtaining a detailed map of the microvasculature30: sensitivity to microscopic vessels (~5–10 µm) comes at the cost of extensive acquisition times (~minutes).

  Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

• We rather show that the relative CBV increase is not correlated with MB speed. This suggests that Doppler-based filtering of low velocities based on sub-spectrum Power Doppler filtering is not be sufficient to extract the complexity of the neurovascular response in particular the discrepancy of relative neurovascular response in arterioles and smaller capillary vessels. The limited 100 µm resolution of fUS imaging is to date not sufficient to separate each vascular compartment. In particular the slow flow near the arteriole vessel walls can simply not be separated from slow flow in capillaries

  Transcranial brain-wide functional ultrasound and ultrasound localization microscopy in mice using multi-array probes | Scientific Reports

• However, the former lacks the fast-scanning capability necessary for whole-brain imaging at high frame rates, while the latter is often limited in sensitivity in imaging blood flow, particularly for transcranial brain imaging.

  Transcranial brain-wide functional ultrasound and ultrasound localization microscopy in mice using multi-array probes | Scientific Reports

• For sample structures that are smaller than 𝐿 𝐴 , that is, 𝐿 𝐴 >> 𝐿 𝐶 , the acoustic field experiences an effective homogeneous medium and the response will, therefore, depend on the average elastic properties of the constituents within this length scale, and thus cannot be resolved individually

  Brillouin microscopy: an emerging tool for mechanobiology | Nature Methods

• This is of utmost importance, as realistic Brillouin signals obtained with a few mW of incident light are only composed of ~104 photons sec–1.

  Brillouin microscopy: an emerging tool for mechanobiology | Nature Methods

• Spectrum acquisition times down to 2 ms over 2 GHz in water and 20 ms over 4 GHz in living specimens are practical

  Brillouin microscopy | Nature Reviews Methods Primers

• At the smaller scale of a single cell, mechanical forces and changes in viscoelastic properties of intracellular and extracellular environments are as important to the cell function as biochemistry

  Brillouin microscopy | Nature Reviews Methods Primers

• incorporating technologies from telecommunications, astrophotonics, multiplexed microscopy, quantum optics and machine learning

  Brillouin microscopy | Nature Reviews Methods Primers