Sleep microstructure organizes memory replay | Nature

The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.

Subjects Consolidation Hippocampus Replay Abstract Recently acquired memories are reactivated in the hippocampus during sleep, an initial step for their consolidation 1 , 2 , 3 . This process is concomitant with the hippocampal reactivation of previous memories 4 , 5 , 6 , posing the problem of how to prevent interference between older and recent, initially labile, memory traces. Theoretical work has suggested that consolidating multiple memories while minimizing interference can be achieved by randomly interleaving their reactivation 7 , 8 , 9 , 10 . An alternative is that a temporal microstr

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