Cellular and signalling mechanisms that regulate the blood–brain barrier | Nature Reviews Molecular Cell Biology
This Review summarizes the latest advances in blood–brain barrier (BBB) research, highlighting how emerging findings on the modulation of BBB function and heterogeneity by cellular interactions and signalling pathways might shape BBB-targeted therapeutics.
St-Amour, I. et al. Brain bioavailability of human intravenous immunoglobulin and its transport through the murine blood–brain barrier. J. Cereb. Blood Flow. Metab. 33, 1983–1992 (2013). Article CAS PubMed Central PubMed Google Scholar Kuzawa, C. W. et al. Metabolic costs and evolutionary implications of human brain development. Proc. Natl Acad. Sci. USA 111, 13010–13015 (2014). Article CAS PubMed Central PubMed Google Scholar Schinkel, A. H. et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood–brain barrier and to increased sensitivity to drugs.…
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