The dTAG system for immediate and target-specific protein degradation - PMC
Dissecting complex biological systems requires target-specific control of protein function or abundance. Genetic perturbations are limited by off-target effects, multi-component complexity, and irreversibility. Most limiting is the requisite delay ...
. Author manuscript; available in PMC: 2018 Dec 17. Published in final edited form as: Nat Chem Biol. 2018 Mar 26;14(5):431–441. doi: 10.1038/s41589-018-0021-8 Abstract Dissecting complex biological systems requires target-specific control of protein function or abundance. Genetic perturbations are limited by off-target effects, multi-component complexity, and irreversibility. Most limiting is the requisite delay from modulation to experimental measurement. To enable the immediate and selective control of single protein abundance, we created a chemical biology system that leverages the…
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