The dTAG system for immediate and target-specific protein degradation - PMC
Dissecting complex biological systems requires target-specific control of protein function or abundance. Genetic perturbations are limited by off-target effects, multi-component complexity, and irreversibility. Most limiting is the requisite delay ...
. Author manuscript; available in PMC: 2018 Dec 17. Published in final edited form as: Nat Chem Biol. 2018 Mar 26;14(5):431–441. doi: 10.1038/s41589-018-0021-8 Abstract Dissecting complex biological systems requires target-specific control of protein function or abundance. Genetic perturbations are limited by off-target effects, multi-component complexity, and irreversibility. Most limiting is the requisite delay from modulation to experimental measurement. To enable the immediate and selective control of single protein abundance, we created a chemical biology system that leverages the…
related reading
- Lysosome-targeting chimaeras for degradation of extracellular proteins | Naturenature.com
- Lysosome-targeting chimeras evolve | Nature Chemical Biologynature.com
- Protein degradation reaches further outnature.com
- PDB101: Molecule of the Month: PROTACs and Molecular Glue Degraderspdb101.rcsb.org
- Development of a targeted BioPROTAC degrader selective for misfolded SOD1nature.com
- Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demandsncbi.nlm.nih.gov
- Engineering Plastic-Degrading Enzymes and PCSK9 Binders with Protein AI Toolsblog.latch.bio
- The current state of the art and future trends in RAS-targeted cancer therapiesnature.com
- Technologies to measure and modulate protein subcellular localizationnature.com
- Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma modelpmc.ncbi.nlm.nih.gov
- A protein tagging system for signal amplification in gene expression and fluorescence imaging - PMCpmc.ncbi.nlm.nih.gov
- A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damagenature.com