PDB-101: Molecule of the Month: PROTACs and Molecular Glue Degraders

Therapeutic molecules that target proteins for degradation

In our cells, proteins are constantly being synthesized in order to carry out the multitude of tasks needed to maintain life. When proteins are damaged, misfolded, or no longer needed, they are degraded and their amino acids recycled. Protein degradation is largely carried out by the ubiquitin-proteasome system, in which proteins are tagged for destruction with a covalently attached chain of ubiquitin molecules. The proteasome recognizes the ubiquitin chain and breaks down the tagged protein into short peptide fragments. Protein ubiquitination is a carefully regulated multistep process.…

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