Lysosome-targeting chimaeras for degradation of extracellular proteins | Nature
Lysosome-targeting chimaeras—in which a small molecule or antibody is connected to a glycopeptide ligand to form a conjugate that can bind a cell-surface lysosome-shuttling receptor and a protein target—are used to achieve the targeted degradation of extracellular and membrane proteins.
Subjects Carbohydrate chemistry Chemical tools Lysosomes Transporters Abstract The majority of therapies that target individual proteins rely on specific activity-modulating interactions with the target protein—for example, enzyme inhibition or ligand blocking. However, several major classes of therapeutically relevant proteins have unknown or inaccessible activity profiles and so cannot be targeted by such strategies. Protein-degradation platforms such as proteolysis-targeting chimaeras (PROTACs) 1 , 2 and others (for example, dTAGs 3 , Trim-Away 4 , chaperone-mediated autophagy targeting 5 a
saved by
related reading
- Protein degradation reaches further outnature.com
- Lysosome-targeting chimeras evolve | Nature Chemical Biologynature.com
- The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease - PMCncbi.nlm.nih.gov
- Frontiers | Therapeutic Antibodies against Intracellular Tumor Antigensfrontiersin.org
- Development of a targeted BioPROTAC degrader selective for misfolded SOD1nature.com
- Targeting UGCG overcomes resistance to lysosomal autophagy inhibitionpmc.ncbi.nlm.nih.gov
- PDB101: Molecule of the Month: PROTACs and Molecular Glue Degraderspdb101.rcsb.org
- Mesa — JURA Bio, Inc.jura.bio
- AlphaProteo generates novel proteins for biology and health researchdeepmind.google
- Manifold Bio | Tissue-targeted medicines, designed in vivomanifold.bio
- Protein World Model | Biohubbiohub.ai
- One-shot design of functional protein binders with BindCraftnature.com