EVOLUTION OF SR PROTEIN AND HnRNP SPLICING REGULATORY FACTORS
The splicing of pre-mRNAs is an essential step of gene expression in eukaryotes. Introns are removed from split genes through the activities of the spliceosome, a large ribonuclear machine that is conserved throughout the eukaryotic lineage. While unicellular ...
. Author manuscript; available in PMC: 2013 Jan 1. Published in final edited form as: Wiley Interdiscip Rev RNA. 2011 Sep 2;3(1):1–12. doi: 10.1002/wrna.100 Abstract The splicing of pre-mRNAs is an essential step of gene expression in eukaryotes. Introns are removed from split genes through the activities of the spliceosome, a large ribonuclear machine that is conserved throughout the eukaryotic lineage. While unicellular eukaryotes are characterized by less complex splicing, pre-mRNA splicing of multicellular organisms is often associated with extensive alternative splicing that…
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