Origin of Spliceosomal Introns and Alternative Splicing
In this work we review the current knowledge on the prehistory, origins, and evolution of spliceosomal introns. First, we briefly outline the major features of the different types of introns, with particular emphasis on the nonspliceosomal self-splicing ...
Abstract In this work we review the current knowledge on the prehistory, origins, and evolution of spliceosomal introns. First, we briefly outline the major features of the different types of introns, with particular emphasis on the nonspliceosomal self-splicing group II introns, which are widely thought to be the ancestors of spliceosomal introns. Next, we discuss the main scenarios proposed for the origin and proliferation of spliceosomal introns, an event intimately linked to eukaryogenesis. We then summarize the evidence that suggests that the last eukaryotic common ancestor (LECA) had…
related reading
- EVOLUTION OF SR PROTEIN AND HnRNP SPLICING REGULATORY FACTORSncbi.nlm.nih.gov
- RNA splicing - Wikipediaen.wikipedia.org
- Retrotransposon - Wikipediaen.wikipedia.org
- Sequence homology - Wikipediaen.wikipedia.org
- Gene isoform - Wikipediaen.wikipedia.org
- cncRNAs: Bi-functional RNAs with protein coding and non-coding functions - PMCncbi.nlm.nih.gov
- Polyadenylation and nuclear export of mRNAs - PMCncbi.nlm.nih.gov
- RNA editing enzymes: structure, biological functions and applicationscellandbioscience.biomedcentral.com
- CG-dinucleotide suppression enables antiviral defense targeting non-self RNA - PMCncbi.nlm.nih.gov
- Transcription (biology)en.wikipedia.org
- Codon usage bias - Wikipediaen.wikipedia.org
- Enhancer (genetics) - Wikipediaen.wikipedia.org