Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases - PMC
The thymine-uracil exchange constitutes one of the major chemical differences between DNA and RNA. Although these two bases form the same Watson-Crick base pairs with adenine and are equivalent for both information storage and transmission, uracil incorporation ...
. Author manuscript; available in PMC: 2009 Aug 27. Published in final edited form as: Acc Chem Res. 2009 Jan 20;42(1):97–106. doi: 10.1021/ar800114w CONSPECTUS The thymine-uracil exchange constitutes one of the major chemical differences between DNA and RNA. Although these two bases form the same Watson-Crick base pairs with adenine and are equivalent for both information storage and transmission, uracil incorporation in DNA is usually a mistake that needs to be excised. There are two ways for uracil to appear in DNA: thymine replacement and cytosine deamination. Most DNA polymerases…
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