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Enhancer (genetics)

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In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription of a particular gene will occur. These proteins are usually referred to as transcription factors. Enhancers are cis-acting. They can be located up to 1 Mbp (1,000,000 bp) away from the gene, upstream or downstream from the start site. There are hundreds of thousands of enhancers in the human genome. They are found in both prokaryotes and eukaryotes.The first discovery of a eukaryotic enhancer was in the immunoglobulin heavy chain gene in 1983. This enhancer, located in the large intron, provided an explanation for the transcriptional activation of rearranged Vh gene promoters while unrearranged Vh promoters remained inactive.

Enhancer (genetics) - Wikipedia Jump to content From Wikipedia, the free encyclopedia DNA sequence that binds activators to increase the likelihood of gene transcription Seen here is a four step diagram depicting the usage of an enhancer. Within this DNA sequence, protein(s) known as transcription factor(s) bind to the enhancer and increase the activity of the promoter. DNA Enhancer Promoter Gene Transcription Activator Protein Mediator Protein RNA Polymerase In genetics , an enhancer is a short (50–1500 bp ) region of DNA that can be bound by proteins ( activators ) to increase the likelihood

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