Epigenetic regulation during cancer transitions across 11 tumour types | Nature
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Nature (2023)Cite this article Metrics details Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis1,2,3,4. Although the genetic contributions to oncogenic transitions have been investigated, epigenetic drivers remain less understood. Here we constructed a pan-cancer epigenetic and transcriptomic atlas using single-nucleus chromatin accessibility data (using single-nucleus assay for transposase-accessible chromatin) from 225 samples and matched single-cell or sing
Main The spatiotemporal dynamics of chromatin decondensation and subsequent binding of transcriptional machinery1 has an important but incompletely understood role in pathogenic transitions in cancer, such as initiation, progression and metastasis2. Epigenetic regulation affects gene expression, lineage determination, cell–cell interactions and therapeutic resistance. In contrast to genetic drivers, such as somatic mutations, epigenetic drivers are less well defined3. However, they might be identified by an enrichment type of analysis, similar to how driver genes are found. Understanding…
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