Matthew Pang

0 followers · 1 following · 829 views

on the atlas — 25

highlights — 22

list every assumption you would make from its inception through its conclusion. Assign two scores to each one: likelihood of success and duration of effort.
Problem choice and decision trees in science and engineering: Cell
WAPL creates a pool of free cohesin, in a process known as cohesin turnover
WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation | Nature Genetics
At least half of essay writing is rereading what you've written and asking is this correct and complete? You have to be very strict when rereading, not just because you want to keep yourself honest, but because a gap between your response and the truth is often a sign of new ideas to be discovered
The Best Essay
They will persecute the greengrocer either because it is expected of them, or to demonstrate their loyalty, or simply as part of the general panorama, to which belongs an awareness that this is how situations of this sort are dealt with, that this, in fact, is how things are always done, particularly if one is not to become suspect oneself. The executors, therefore, behave essentially like everyone else, to a greater or lesser degree: as components of the post-totalitarian system, as agents of its automatism, as petty instruments of the social auto-totality.
Havel, Power of the Powerless, 1978
You have no idea what’s actually happening about the ground. You are not influencing any policy. You’re not convincing anyone, if anything you might make them less likely to support your cause because you’re being so morally righteous about it which is annoying to them.
Take the Clearpill - Erik Torenberg
Verbally, it might be expressed this way: "I, the greengrocer XY, live here and I know what I must do. I behave in the manner expected of me. I can be depended upon and am beyond reproach. I am obedient and therefore I have the right to be left in peace." This message, of course, has an addressee: it is directed above, to the greengrocer's superior, and at the same time it is a shield that protects the greengrocer from potential informers. The slogan's real meaning, therefore, is rooted firmly in the greengrocer's existence. It reflects his vital interests.
Havel, Power of the Powerless, 1978
Keeping score and needing reconciliation will make you resentful, because the ball lies all the time. If you stopped playing basketball every time the ball lied, you’d stop playing completely. And if you avoided everyone who treated you unfairly at some point, you’d probably just be alone.
Let Sleeping Dogs Lie - Erik Torenberg
Kids just plunge in and build their treehouse without worrying about whether they're wasting their time, or how it compares to other treehouses. And frankly we could learn a lot from kids here. The high standards most grownups have for "real" work do not always serve us well.
A Project of One's Own
People who've never experienced the thrill of working on a project they're excited about can't distinguish this kind of working long hours from the kind that happens in sweatshops and boiler rooms, but they're at opposite ends of the spectrum. That's why it's a mistake to insist dogmatically on "work/life balance." Indeed, the mere expression "work/life" embodies a mistake: it assumes work and life are distinct. For those to whom the word "work" automatically implies the dutiful plodding kind, they are. But for the skaters, the relationship between work and life would be better represented by …
A Project of One's Own
Because to the kind of people who like working this way, nothing else feels as right. You feel as if you're an animal in its natural habitat, doing what you were meant to do — not always happy, maybe, but awake and alive.
A Project of One's Own
we are winning but only under our assumptions of the rules. This is not working simply calling their game and referees dumb. We first have to acknowledge that their game is: A) Different. It is focused on power. B) Parasitic on our game and on logic. C) Extremely fit in the Darwinian sense.
The case for and against Liberalism - Erik Torenberg
When an objectively worse performing group (by outcomes) encounters an objectively better performing group (by outcomes), the worse performing group's response, nearly all the time, is to build a giant edifice of cope.
Group Narcissism - Erik Torenberg
patients with increased TBX21 regulon activities tend to have a better survival, whereas increased CDX1 and EGR1 portends poorer prognosis.
Epigenetic regulation during cancer transitions across 11 tumour types | Nature
By conducting trajectory analysis of tumour and normal epithelial cells, we observed that all of the paired primary–metastatic samples followed a linear trajectory, gradually progressing from normal (if available) to primary to metastatic cells (Fig. 4e,f and Extended Data Fig. 9a–g). This suggests that trajectory pseudotimes reflect the metastatic process. We found that the trajectories of samples were positively correlated with known EMT-specific motifs and other motifs implicated in the metastases, such as SNAI1 and PBX341 (Fig. 4e,f, Supplementary Note 5 and Supplementary Table 7).
Epigenetic regulation during cancer transitions across 11 tumour types | Nature
FOX-family TFs among the most significant downregulated TFs across cancers. FOX-family motifs were also enriched in DACRs that were upregulated in primary PDAC and UCEC (Supplementary Note 4). FOXA1 represses genes associated with EMT45 and FOXN3 represses growth and invasion in some cancers46,47.
Epigenetic regulation during cancer transitions across 11 tumour types | Nature
Examples of tissue-specific regulons include FOXA1 and GATA3 in BRCA non-basal cancer, KLF4 and FOSL1 in CESC and HNSCC, HNF1A and KLF9 in ccRCC, and HNF4G and GATA6 in CRC and PDAC.
Epigenetic regulation during cancer transitions across 11 tumour types | Nature
following normal cell populations as the closest normal cells (CNCs): luminal mature cells for BRCA of the non-basal subtypes; luminal progenitor cells for BRCA of the basal subtype; ductal-like-2 cells for PDAC; distal stem cells for CRC; secretory endometrial epithelial cells for UCEC and OV; normal squamous cells for HNSCC and CESC; melanocytes for SKCM; proximal tubule cells for ccRCC; and oligodendrocyte precursor cells (OPCs) for GBM.
Epigenetic regulation during cancer transitions across 11 tumour types | Nature
DACRs include the promoters of tissue-specific genes, such as keratin genes in squamous cancers, PAX8 in OV and UCEC, GATA3 in non-basal BRCA, PTPRZ1 in GBM and PAX3 in SKCM
Epigenetic regulation during cancer transitions across 11 tumour types | Nature
need for comprehensive approaches to map hypothalamic cells and circuits supporting both sleep and thermoregulation at single-cell resolution.
Sleep and the hypothalamus | Science
Local warming or electrical stimulation of the POA causes hypothermia, whereas lesions or pharmacological silencing block the homeostatic regulation of an animal’s core body temperature
Sleep and the hypothalamus | Science
The PROTAC thus acts as a bridge that brings the target of interest into close proximity with an E3 ubiquitin ligase (Fig 1). This enables the E3 ligase complex to catalyze ubiquitination of the target. The resulting polyubiquitin chain flags the target protein for degradation by the proteasome.
Unlock new parts of the proteome with PROTAC, a promising emerging technology
When the white dust settles, and the bereaved are alone in their houses, there will be nothing but grief around them, and nothing is more real than that. In short, people may at last be ready to say what they wholeheartedly believe. The kindness of people toward others in distress is real. There is nothing to see through in that. Honor and fair play? Real. And the preciousness of ordinary living is real as well--all to be taken seriously, perhaps, in a new and chastened time. The greatness of the country: real. The anger: real. The pain: too real.
The Age Of Irony Comes To An End - TIME