Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials - PMC
The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Department of Population Health Sciences, Duke University, Durham, North Carolina; Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA Medical Center, Durham, North Carolina Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA Medical Center, Durham, North Carolina; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill Nonadh
. Author manuscript; available in PMC: 2022 Aug 3. Published in final edited form as: JAMA. 2021 Aug 3;326(5):433–434. doi: 10.1001/jama.2021.2825 Nonadherence in a randomized clinical trial (RCT) occurs when study participants do not follow the randomly assigned treatment protocol. Reasons for nonadherence may include the study participant not taking trial medications, crossing over to the other intervention being studied, or accessing treatment outside of the trial. Nonadherence also may occur when the clinician is unable to complete the assigned therapy (eg, a surgical procedure) as…
related reading
- CAUSE, EFFECT, AND THE STRUCTURE OF THE SOCIAL WORLD. MEGAN T. STEVENSONbu.edu
- Exploring the barriers to the antiretroviral therapy adherence among people living with HIV in Bangladesh: A qualitative approachpmc.ncbi.nlm.nih.gov
- Critical review of sham surgery clinical trials: Confounding factors analysis - PMCncbi.nlm.nih.gov
- Clinical trial - Wikipediaen.wikipedia.org
- Clinic-in-the-Loopasimov.press
- 傾向分數分析介紹（第2篇，共2篇）－ 晨晰統計林星帆顧問整理dasanlin888.pixnet.net
- Cluster Randomized Trials - Rethinking Clinical Trialsrethinkingclinicaltrials.org
- “Real world” eligibility for aducanumab: A Podcast with Tim Anderson and Marco Canevelligeripal.org
- 10 Complex Diff-in-Diff Designs – Causal Inference<br/>*The Remix*mixtape.scunning.com
- Detecting interference: An A/B test of A/B testslinkedin.com
- Cochrane Handbook for Systematic Reviews of Interventions (current version)cochrane.org
- Pediatric dental treatments with pharmacological and non-pharmacological interventions: a cross‐sectional study | BMC Oral Health | Springer Nature Linkbmcoralhealth.biomedcentral.com