RNA Interference–Based Therapy and Its Delivery Systems - PMC
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. Author manuscript; available in PMC: 2019 Mar 1. Published in final edited form as: Cancer Metastasis Rev. 2018 Mar;37(1):107–124. doi: 10.1007/s10555-017-9717-6 Abstract RNA interference (RNAi) is considered a highly specific approach for gene silencing and holds tremendous potential for treatment of various pathologic conditions such as cardiovascular diseases, viral infections, and cancer. Although gene silencing approaches such as RNAi are widely used in preclinical models, the clinical application of RNAi is challenging primarily because of the difficulty in achieving successful…
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