Programmed exosome fusion for energy generation in living cells | Nature Catalysis
The design of artificial organelles for applications in living cells faces several challenges such as cellular uptake, stability and biocompatibility. Now, fusion of exosomes creates beneficial nanoreactors and their use for compartmentalized biocatalytic cascade reactions in cells is demonstrated.
Data availability Data used to generate results in the current study are available from the corresponding author on reasonable request. Source data are provided with this paper. References Agapakis, C. M., Boyle, P. M. & Silver, P. A. Natural strategies for the spatial optimization of metabolism in synthetic biology. Nat. Chem. Biol. 8, 527–535 (2012). Article CAS PubMed Google Scholar Hammes, G. G. & Wu, C.-W. Regulation of enzyme activity. Science 172, 1205–1211 (1971). Article Google Scholar Kondo, S. & Miura, T. Reaction-diffusion model as a framework for understanding…
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