Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR

Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation. However, these proteins have some limitations that single-domain antibodies could ...

Pharmaceutics . 2020 Sep 30;12(10):937. doi: 10.3390/pharmaceutics12100937 Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR Elodie Pothin Elodie Pothin 1 Antibody Engineering Platform, Structural Biology and Chemistry Department, Institut Pasteur, 75015 Paris, France; elodie.pothin@pasteur.fr 2 Tissue Barriers, Rare and Neurological Diseases TA Department, Sanofi, 91161 Chilly-Mazarin, France Find articles by Elodie Pothin 1, 2 , Dominique Lesuisse Dominique Lesuisse 2 Tissue Barriers, Rare and Neurological Diseases TA Department, Sanofi, 91161 Chilly-Mazarin, France Find ar

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