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Etiology, diagnosis, and treatment of hypoaldosteronism (type 4 RTA) - UpToDate

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Etiology, diagnosis, and treatment of hypoaldosteronism (type 4 RTA) INTRODUCTION Hypoaldosteronism should be considered in any patient with persistent hyperkalemia in whom there is no obvious cause such as kidney failure or the use of potassium supplements or a potassium-sparing diuretic [1-3]. The rise in the plasma potassium in this disorder reflects the major role played by aldosterone in urinary potassium excretion. In addition to hyperkalemia, hypoaldosteronism is usually associated with a mild metabolic acidosis with a normal anion gap (ie, a hyperchloremic acidosis) that has been…

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