Diagnosis of primary aldosteronism - UpToDate

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INTRODUCTION Nonsuppressible (primary) hypersecretion of aldosterone is an underdiagnosed cause of hypertension. The classic presenting signs of primary aldosteronism are hypertension and hypokalemia, but potassium levels are frequently normal in modern-day series of primary aldosteronism. The most common subtypes of primary aldosteronism are: ● Unilateral aldosterone-producing adenomas (APAs; ≥10 mm) or aldosterone-producing micronodules (<10 mm) ● Bilateral idiopathic hyperaldosteronism (IHA; bilateral adrenal hyperplasia) Less common forms include: ● Familial hyperaldosteronism (FH) types I to IV and primary aldosteronism with seizures and neurologic abnormalities (PASNA) (see "Familial hyperaldosteronism") ● Unilateral hyperplasia or primary adrenal hyperplasia (caused by micronodular or macronodular hyperplasia of the zona glomerulosa of one adrenal gland) ● Pure aldosterone-producing adrenocortical carcinomas ● Ectopic aldosterone-producing tumors The diagnosis of primary aldoste

Diagnosis of primary aldosteronism INTRODUCTION Autonomous (primary) hypersecretion of aldosterone is an underdiagnosed cause of hypertension. The classic presenting signs of primary aldosteronism are hypertension and hypokalemia, but potassium levels are frequently normal in modern-day series of primary aldosteronism. The most common subtypes of primary aldosteronism are: ●A unilateral aldosterone-producing adenoma (APA; ≥10 mm) or aldosterone-producing micronodule (<10 mm) ●Bilateral idiopathic hyperaldosteronism (IHA; bilateral adrenal hyperplasia) Less common forms include:…

Diagnosis of primary aldosteronism - UpToDate

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