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Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells | eLife

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Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale organization. The Ciona cardiopharyngeal progenitors provide the simplest model of collective cell migration, with cohesive bilateral cell pairs polarized along the leader-trailer migration path while moving between the ventral epidermis and trunk endoderm. We use the Cellular Potts Model to computationally probe the distributions of forces consistent with shapes and collective polarity of migrating cell pairs. Combining computational modeling, confocal microscopy, and molecular perturbations, we identify cardiopharyngeal progenitors as the simplest cell collective maintaining supracellular polarity with differential distributions of protrusive forces, cell-matrix adhesion, and myosin-based retraction forces along the leader-trailer axis. 4D simulations and experimental o

Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells | eLife Version of Record January 11, 2022 Version of Record December 23, 2021 Accepted Manuscript November 29, 2021 Download Cite Share Comment Open annotations (there are currently 0 annotations on this page). 1,610 views 237 downloads 12 citations Altmetric provides a collated score for online attention across various platforms and media. See more details Share this article Doi Copy to clipboard Cite this article Yelena Y Bernadskaya Haicen Yue Calina Copos Lionel

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