Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo | Nature

Stiffening of the mesoderm owing to an accumulation of cells triggers collective migration of neural crest cells during morphogenesis.

Subjects Cell biology Morphogenesis Abstract Collective cell migration is essential for morphogenesis, tissue remodelling and cancer invasion 1 , 2 . In vivo , groups of cells move in an orchestrated way through tissues. This movement involves mechanical as well as molecular interactions between cells and their environment. While the role of molecular signals in collective cell migration is comparatively well understood 1 , 2 , how tissue mechanics influence collective cell migration in vivo remains unknown. Here we investigated the importance of mechanical cues in the collective migration of

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