✳flâneur — a map of the web's best reading

Steering cell migration by alternating blebs and actin-rich protrusions | BMC Biology

link.springer.com · 314 words · saved by 1 readers

High directional persistence is often assumed to enhance the efficiency of chemotactic migration. Yet, cells in vivo usually display meandering trajectories with relatively low directional persistence, and the control and function of directional persistence during cell migration in three-dimensional environments are poorly understood. Here, we use mesendoderm progenitors migrating during zebrafish gastrulation as a model system to investigate the control of directional persistence during migration in vivo. We show that progenitor cells alternate persistent run phases with tumble phases that result in cell reorientation. Runs are characterized by the formation of directed actin-rich protrusions and tumbles by enhanced blebbing. Increasing the proportion of actin-rich protrusions or blebs leads to longer or shorter run phases, respectively. Importantly, both reducing and increasing run phases result in larger spatial dispersion of the cells, indicative of reduced migration precision. A p

Steering cell migration by alternating blebs and actin-rich protrusions Research article Open access Published: 02 September 2016 Volume 14 , article number 74 ( 2016 ) Cite this article You have full access to this open access article Download PDF Save article View saved research BMC Biology Aims and scope Submit manuscript Steering cell migration by alternating blebs and actin-rich protrusions Download PDF Abstract Background High directional persistence is often assumed to enhance the efficiency of chemotactic migration. Yet, cells in vivo usually display meandering trajectories with relati

Explore this link on the map →

related reading