Dr. Samantha Stehbens PhD on Twitter: "Buckle in, it is #microtubule cell migration story time! We reveal a new role for microtubules as cellular sensors which detect and respond to compressive forces, enabling movement and ensuring survival in mechanically demanding environments; just like this little guy squeezing… https://t.co/bbyRR2g8aM" / Twitter

To view keyboard shortcuts, press question mark View keyboard shortcuts Messages 1 Thread See new Tweets Conversation Dr. Samantha Stehbens PhD @SamStehbens · Mar 30 We knew that repair of this damage and strengthening of polymers is assisted by the microtubule +TIP protein CLASP. Strikingly, we found that when cells lack CLASPs, they pop (!!) when they try to squeeze through tight spaces. 3/10 GIF 2 15 107 7,135 Dr. Samantha Stehbens PhD @SamStehbens · Mar 30 In confined cells that lack CLASPs, microtubules rapidly grow and shrink, coincident with crazy membrane blebbing before ultimately rupturing. We wondered if CLASPs were required for microtubules to resist compressive forces in confinement. 4/10 2 1 33 4,150 Dr. Samantha Stehbens PhD @SamStehbens · Mar 30 In confined cells the occluded nucleus acts like a plug, creating front and rear compartments. The rear compartment is full of microtubules forming a ‘cushion’! As the rear compartment shrinks, it compresses these microtubules,

A/Prof Samantha Stehbens PhD @SamStehbens Buckle in, it is #microtubule cell migration story time! We reveal a new role for microtubules as cellular sensors which detect and respond to compressive forces, enabling movement and ensuring survival in mechanically demanding environments; just like this little guy squeezing through here. 1/10 GIF 1:14 PM · Mar 30, 2023 231.3K Views 31 0 3 1 208 0 2 0 8 1.1K 0 1 . 1 K 154 0 1 5 4

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