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Research | Levchenko Lab

levchenkolab.yale.edu · 2,103 words · saved by 1 readers

Cell behavior and functions are affected by its environment, which includes neighboring cells. This effect can be done by contact or by secreting soluble molecules. We investigate angiogenesis and tumor metastasis by studying interaction between tumor cells and endothelial cells for a wide range of scales: from single cell, to a group of cells to colonies. We are also interested in interactions between neuron and muscle cells, stem cell and differentiated cells, etc. Biological networks are graphical representations of complex systems and processes, such as gene regulation, metabolism, or signal transduction. Large-scale topological analysis of these networks has revealed that they are not randomly organized. The intricate relations between their structure, function and dynamics need to be further investigated. We study the dependence and interplay between network topology and the dynamics of the biological processes within a cell. We investigate ways in which network topology may have

Research | Levchenko Lab Skip to main content You are here Home » Research Research Sort research by Biological Questions - Sort research by Technical Approaches Signaling Pathway Dynamics Signal transduction pathways, as the name implies, are often thought of as chains of molecules that simply relay external signals to end effectors. However, this is a misnomer because signaling pathways execute other important functions (e.g. signal amplification, signal processing, etc.) and can implement critical systems features (e.g. robustness, sensitivity, memory, etc.). Understanding such properties i

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