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Molecules and Cells – Mahadevan Natural Philosophy

softmath.seas.harvard.edu · 1,464 words · saved by 1 readers

Over the last few decades, structural biologists have delivered a treasure-trove of data on the shapes and sizes of large biomacromolecules and their assemblies. When this information is combined with aspects of their kinetics, we can begin to ask questions about how structure impacts function dynamically at both the level of the individual molecule and in polymeric filaments, networks and larger assemblies. We are particularly interested in the statistical and continuum mechanics of macromolecular assemblies such as disordered cytoskeletal-like networks of cross-linked actin, ordered assemblies such as microtubules, actin bundles, DNA-loops etc. in the context of questions such as the linear and nonlinear rheology of these “living” materials”, the kinetics of growth and shrinkage, and the mechanochemistry of active biological engines driven by growth, shrinkage and spring-like behavior. Recently, we have also become interested in how we might control the formation and dissolution of

Molecules and Cells – Mahadevan Natural Philosophy Molecules and Cells Over the last few decades, structural biologists have delivered a treasure-trove of data on the shapes and sizes of large biomacromolecules and their assemblies. When this information is combined with aspects of their kinetics, we can begin to ask questions about how structure impacts function dynamically at both the level of the individual molecule and in polymeric filaments, networks and larger assemblies. We are particularly interested in the statistical and continuum mechanics of macromolecular assemblies such as

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