flâneur

Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale | Nature Methods

nature.com · 9,150 words · saved by 1 readers

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Nature Methods volume  19,  pages 1004–1012 (2022)Cite this article 30k Accesses 130 Citations 169 Altmetric Metrics details The advent of neuroimaging has increased our understanding of brain function. While most brain-wide functional imaging modalities exploit neurovascular coupling to map brain activity at millimeter resolutions, the recording of functional responses at microscopic scale in mammals remains the privilege of invasive electrophysiological or optical approaches, but is mostly restricted to either the cortical surface or the vicinity of implanted sensors. Ultrasound localization microscopy (UL

Main Obtaining quantitative information on the function and dysfunction of organs across multiple scales is a challenge of biomedical imaging, as diseases initially emerge locally at the cellular level deep within organs before eliciting large-scale and delayed observable symptoms. In the brain, the interaction between cells and their supplying vessels reaches a high complexity, making such imaging paramount. To support the metabolic demand of billions of neurons, the cerebrovascular system has evolved into a multiscale network, ensuring finely regulated blood supply through precise…

saved by

related reading