flâneur

Owen Wang

3 followers · 4 following · 291 views

on the atlas — 32

highlights — 20

  • More compute, more storage, more copies of itself. To write the science paper.
    Danger, AI Scientist, Danger - by Zvi Mowshowitz
  • For example, in one run, The A I Scientist wrote code in the experiment file that initiated a system call to relaunch itself, causing an uncontrolled increase in Python processes and eventually necessitating manual intervention.
    Danger, AI Scientist, Danger - by Zvi Mowshowitz
  • This is a market failure just like the carbon dioxide problem: There’s no incentive for emitters to reduce emissions because they pay the full costs of the emissions reductions but capture only a small fraction of the benefits of avoiding the impacts of climate change. In such a case, the rational thing for a profit-seeker is to keep emitting carbon dioxide.
    Why is the Texas grid in such bad shape?
  • This is one of the reasons, by the way, why Texas is so popular with corporations. They are never held accountable for pushing their costs onto society
    Why is the Texas grid in such bad shape?
  • You don’t get PTO, so it will feel like you’re losing money when you take a vacation. It’s strange.
    Everything I know about freelancing | Andy Adams
  • What may be good for the world is tougher from a business perspective. The problem is that once a customer has their designed organism, they can use it to grow as much of the programmed output as they want without Ginkgo
    Ginkgo Bioworks: The Organism Company
  • The teams can spend their time focusing on their most ambitious ideas because they are building using a shared Parts Registry, a Distribution Kit, and a set of Assembly Standards
    Ginkgo Bioworks: The Organism Company
  • With this incentive structure, biotech has become an industry with public companies that have hundreds of employees and no product
    Ginkgo Bioworks: The Organism Company
  • This change in measurement technology was a really big deal. After decades studying individual genes, geneticists began studying thousands of genes at a time
    Ginkgo Bioworks: The Organism Company
  • At Palantir, we didn’t believe in heavy processes, because we felt that formulas and playbooks tacitly give people permission to stop thinking for themselves.
    The unconventional Palantir principles that catalyzed a generation of startups
  • Intrinsic cell characteristics, such as suitability for suspension growth, doubling times, growth rates, metabolism, differentiation capacity, and genomic stability can vary between cell type and species.
    The science of cultivated meat | GFI
  • “People are used to paying a lot of money for sushi products,” Kolbeck said. “The difference between what we need to make our costs be for a piece of high-grade salmon or tuna sushi are a couple of orders of magnitude larger than chicken. I have a really hard time believing in the next five years that we’re going to have a chicken burger that’s at the same cost of conventional chicken products. I think we’re more likely to show up in places like your favorite sushi restaurant, where you’re used to paying a little bit more for fish and you might already be in an exploratory sort of state of min…
    Lab-grown meat is supposed to be inevitable. The science tells a different story.
  • Sterility isn’t the only challenge that becomes more grave at larger production volumes. Bigger bioreactors all also struggle to provide all of the cells with the same amount of nutrients and oxygen. The only solution is to stir the cells more rapidly, or blow more oxygen in—but both of these approaches can be fatal. Because they lack a rigid cell wall, animal cells are prone to “shear stress”; they’re fragile little things that can are easily torn apart by rising air bubbles, cell-to-cell collisions, and rotating impellers. This need for increased stirring and oxygen has historically put prac…
    Lab-grown meat is supposed to be inevitable. The science tells a different story.
  • If companies haven’t made progress on cell density, in his view, the whole idea of cultured meat at scale isn’t a business plan: It’s speculation
    Lab-grown meat is supposed to be inevitable. The science tells a different story.
  • But the GFI-commissioned report also found the cost of cultured meat could drop down to a mere $17 per kilo if the recombinant proteins and growth factors typically supplied in serum could be bought more cheaply. A recombinant protein like transferrin can go for $260 a gram. Growth factors like TGF-β can cost several million dollars a gram
    Lab-grown meat is supposed to be inevitable. The science tells a different story.
  • “I think having clean rooms, per se, as they are in biopharma—I’m uncertain if that’s an assumption that should be taken here,” he said. “I don’t know the answers to these questions, and I honestly don’t think anyone does.”
    Lab-grown meat is supposed to be inevitable. The science tells a different story.
  • According to Humbird’s report, those economics will likely one day limit the practical size of cultured meat facilities: They can only be big enough to house a sweet spot of two dozen 20,000-liter bioreactors, or 96 smaller perfusion reactors. Any larger, and the clean room expenses start to offset any benefits from adding more reactors. The construction costs grow faster than the production costs drop.
    Lab-grown meat is supposed to be inevitable. The science tells a different story.
  • It may not matter if governments end up allowing cultured meat facilities to produce at food-grade specs, critics say—cells are so intensely vulnerable that they’ll likely need protection to survive
    Lab-grown meat is supposed to be inevitable. The science tells a different story.
  • There are 4 main inputs to cultivate meat: 1. Cell Source 2. Cell Culture Media 3. Bioreactor 4. Scaffold. Each input may have its own unique supply chain and production process
    Lab Grown Meat - Everything You Need to Know About Cultured Meat
  • A prototypical head of engineering will be skilled at organizational design, process design, business strategy, recruiting, mentoring, coaching, public speaking, written communication, have a broad personal network, and have a broad foundation from product engineering to infrastructure engineering.
    Career narratives. | Irrational Exuberance