Reproducible brain-wide association studies require thousands of individuals | Nature
Combined data from three large studies, with a total sample size of around 50,000 individuals, indicate that many previous studies linking the brain to complex phenotypes have been statistically underpowered, producing inflated and irreproducible effects.
Main MRI data (such as cortical thickness or resting-state functional connectivity (RSFC)) are increasingly being used for the ambitious task of relating individual differences in brain structure and function to typical variation in complex psychological phenotypes (for example, cognitive ability and psychopathology). To clearly distinguish such BWAS from other neuroimaging research, we formally define them as ‘studies of the associations between common inter-individual variability in human brain structure/function and cognition or psychiatric symptomatology’. Classically univariate, BWAS…
saved by
related reading
- A Practical Guide for Improving Transparency and Reproducibility in Neuroimaging Research | PLOS Biologyjournals.plos.org
- [2107.06867] Comparison of Canonical Correlation and Partial Least Squares analyses of simulated and empirical dataarxiv.org
- An assessment of the autism neuroimaging literature for the prospects of re-executabilityf1000research.com
- Gap Mapgap-map.org
- Neuroscience is pre-paradigmatic. Consciousness is whytheintrinsicperspective.com
- A heart of firemarleyx.com
- Neurdiness Blog | Grace W. Lindsay | Computational Neuroscientist | Page 2gracewlindsay.com
- Never Cross a River Four Feet Deep on Averagesubstack.com
- State of Brain Emulation Report 2025 | Research Overviewbrainemulation.mxschons.com
- THINGS-data, a multimodal collection of large-scale datasets for investigating object representations in human brain and behavior | eLifeelifesciences.org
- Reversals in psychologygleech.org
- Mapping the Brain for Alignment | IFPifp.org