Depression and antidepressants: a neurotrophic model for stress-related mood disorders

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Depression and antidepressants: a neurotrophic model for stress-related mood disorders A Neurotrophic Model for Stress-Related Mood Disorders by Duman RS, Monteggia LM. Division of Molecular Psychiatry (RSD), Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut. Biol Psychiatry . 2006 Apr 19; ABSTRACT T here is a growing body of evidence demonstrating that stress decreases the expression of brain-derived neurotrophic factor (BDNF) in limbic structures that control mood and that antidepressant treatment reverses or blocks the effects of stress.

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