Slate Star Codex

Thanks for bearing with me the past few months. My new blog is at https://astralcodexten.substack.com/. I’ll try to have a less unwieldy domain name working soon.

I. One of psychiatry’s many embarrassments is how many of our drugs get discovered by accident. They come from random plants or shiny rocks or stuff Alexander Shulgin invented to get high. But every so often, somebody tries to do things the proper way. Go over decades of research into what makes psychiatric drugs work and how they could work better. Figure out the hypothetical properties of the ideal psych drug. Figure out a molecule that matches those properties. Synthesize it and see what happens. This was the vision of vortioxetine and vilazodone, two antidepressants from the early…

saved by

• abinaya dinesh
• Aadhithyan K S
• Grace Gong
• Stephen Fay
• Yudhister Joel Kumar
• Rémi COLIN
• Atticus Wang

related reading

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• I take antidepressants. You’re welcome – Aceso Under Glassacesounderglass.com
• Top Postsslatestarcodex.com
• Some Predictions About the Future of “Withdrawal Studies”psychiatrymargins.com
• The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it | Alex’s blogatelfo.github.io
• The serotonin theory of depression: a systematic umbrella review of the evidencenature.com
• Atomoxetine: a novel treatment for child and adult ADHD - PMCpmc.ncbi.nlm.nih.gov
• The Challenge of Going Off Psychiatric Drugs | The New Yorkernewyorker.com
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• Club Med | Broadcastpioneerworks.org