Slate Star Codex
Thanks for bearing with me the past few months. My new blog is at https://astralcodexten.substack.com/. I’ll try to have a less unwieldy domain name working soon.
I. One of psychiatry’s many embarrassments is how many of our drugs get discovered by accident. They come from random plants or shiny rocks or stuff Alexander Shulgin invented to get high. But every so often, somebody tries to do things the proper way. Go over decades of research into what makes psychiatric drugs work and how they could work better. Figure out the hypothetical properties of the ideal psych drug. Figure out a molecule that matches those properties. Synthesize it and see what happens. This was the vision of vortioxetine and vilazodone, two antidepressants from the early…
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