Very long-term memories may be stored in the pattern of holes in the perineuronal net

N/A

Very long-term memories may be stored in the pattern of holes in the perineuronal net Roger Y. Tsien1 Department of Pharmacology, Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647 Contributed by Roger Y. Tsien, June 3, 2013 (sent for review May 16, 2013) A hypothesis and the experiments to test it propose that very A proteoglycan-rich matrix called the perineuronal net (PNN) long-term memories, such as fear conditioning, are stored as the has long been known to…

related reading

• Engram neurons: Encoding, consolidation, retrieval, and forgetting of memorynature.com
• Mind the Matrix: Looking Beyond Old Cells in Brain Agingamaranthfoundation.substack.com
• Memory formation in the absence of experiencenature.com
• Molecular Mechanisms of the Memory Tracencbi.nlm.nih.gov
• Volitional control of individual neurons in the human brainpmc.ncbi.nlm.nih.gov
• Spatially embedded recurrent neural networks reveal widespread links between structural and functional neuroscience findingsnature.com
• 20 years of the default mode network: A review and synthesismed.stanford.edu
• Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context - PMCpmc.ncbi.nlm.nih.gov
• Stress effects on the hippocampus: a critical review - PMCpmc.ncbi.nlm.nih.gov
• Memory Synapses Are Defined by Distinct Molecular Complexes: A Proposalfrontiersin.org
• Centre for NeuroScience, Indian Institute of Science, Bangalorecns.iisc.ac.in
• Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imagingnature.com