Very long-term memories may be stored in the pattern of holes in the perineuronal net

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Very long-term memories may be stored in the pattern of holes in the perineuronal net Roger Y. Tsien1 Department of Pharmacology, Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647 Contributed by Roger Y. Tsien, June 3, 2013 (sent for review May 16, 2013) A hypothesis and the experiments to test it propose that very A proteoglycan-rich matrix called the perineuronal net (PNN) long-term memories, such as fear conditioning, are stored as the has long been known to…

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