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Comparison of the 7th and proposed 8th editions of the AJCC/UICC TNM staging system for non-small cell lung cancer undergoing radical surgery | Scientific Reports

nature.com · 3,733 words · saved by 1 readers

The present study aims to compare the 7th and the proposed 8th edition of the AJCC/UICC TNM staging system for NSCLC in a cohort of patients from a single institution. A total of 408 patients with NSCLC who underwent radical surgery were analyzed retrospectively. Survivals were analyzed using the Kaplan –Meier method and were compared using the log-rank test. Multivariate analysis was performed by the Cox proportional hazard model. The Akaike information criterion (AIC) and C-index were applied to compare the two prognostic systems with different numbers of stages. The 7th AJCC T categories, the proposed 8th AJCC T categories, N categories, visceral pleural invasion, and vessel invasion were found to have statistically significant associations with disease-free survival (DFS) on univariate analysis. In the 7th edition staging system as well as in the proposed 8th edition, T categories, N categories, and pleural invasion were independent factors for DFS on multivariate analysis. The AIC value was smaller for the 8th edition compared to the 7th edition staging system. The C-index value was larger for the 8th edition compared to the 7th edition staging system. Based on the data from our single center, the proposed 8th AJCC T classification seems to be superior to the 7th AJCC T classification in terms of DFS for patients with NSCLC underwent radical surgery.

Introduction Despite screening and treatment progress, Lung cancer remains the leading cause of cancer death in the People’s Republic of China as well as worldwide. In 2015, an estimated 733,300 new cases of lung and bronchial cancer will be diagnosed, and 610,200 deaths are estimated to occur because of the disease1. Studies have shown, the overall 5-year relative survival rate for all lung cancer patients was less than 20%. On contrast, those patients with operable pulmonary tumors experienced more favorable outcomes that their 5-year survival rate ranged from 20% to 70%2. Accurate…

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