Drug-induced liver injury - UpToDate

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INTRODUCTION Numerous drugs, both prescription and over-the-counter, herbal products, or toxins can cause hepatotoxicity through a variety of mechanisms. A high index of suspicion is often necessary to expeditiously establish the diagnosis. This topic will review the epidemiology, clinical manifestations, diagnosis, and management of drug-induced liver injury (DILI). The metabolism of drugs by the liver, the mechanisms by which drugs might injure the liver, and the use of medications in patients with liver disease are discussed separately. (See "Drugs and the liver: Metabolism and…

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