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Acute liver failure in adults: Etiology, clinical manifestations, and diagnosis - UpToDate

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Acute liver failure in adults: Etiology, clinical manifestations, and diagnosis Authors:Eric Goldberg, MDSanjiv Chopra, MD, MACP, FRCP (London)Jonah N Rubin, MD Section Editor:Robert S Brown, Jr, MD, MPH Deputy Editor:Claire Meyer, MD Literature review current through: Aug 2026. This topic last updated: Dec 03, 2024. INTRODUCTION Acute liver failure is characterized by acute liver injury, hepatic encephalopathy (altered mental status), and an elevated prothrombin time/international normalized ratio (INR). It has also been referred to as fulminant hepatic failure, acute hepatic necrosis,…

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