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Management of chronic hepatitis C virus infection: Antiviral retreatment following relapse in adults - UpToDate

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Нерatitiѕ C virus (ΗСV) can cause both acute and chronic hepatitis. The acute process is self-limited, rarely causes hepatic failure, and usually leads to chronic infection. Chronic НCV infection often follows a progressive course over many years and can ultimately result in ϲirrhоѕiѕ, hepatocellular carcinoma, and the need for liver transplantation. (See "Clinical manifestations and natural history of chronic hepatitis C virus infection".) Successful antiviral treatment of chronic ΗCV infection halts the progression of liver disease and is associated with improvement in liver-related morbidity and mortality. Although contemporary antiviral regimens are highly effective, a small minority does not respond to initial treatment. In contrast to the limited evaluation needed prior to initial treatment, patients with relapse warrant more detailed assessment and monitoring to optimize the likelihood of cure with retreatment. This topic will review the pretreatment evaluation, antiviral select

Management of chronic hepatitis C virus infection: Antiviral retreatment following relapse in adults INTRODUCTION Hepatitis C virus (HCV) can cause both acute and chronic hepatitis. The acute process is self-limited, rarely causes hepatic failure, and usually leads to chronic infection. Chronic HCV infection often follows a progressive course over many years and can ultimately result in cirrhosis, hepatocellular carcinoma, and the need for liver transplantation. (See "Clinical manifestations and natural history of chronic hepatitis C virus infection".) Successful antiviral treatment of…

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