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Collective curvature sensing and fluidity in three-dimensional multicellular systems | Nature Physics

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Many important cellular structures in the body are curved at the scale of multiple cell lengths. Cells respond collectively to this curvature, and it influences their migration during development and growth.

Subjects Biological physics Biophysics Abstract Collective cell migration is an essential process throughout the lives of multicellular organisms, for example in embryonic development, wound healing and tumour metastasis. Substrates or interfaces associated with these processes are typically curved, with radii of curvature comparable to many cell lengths. Using both artificial geometries and lung alveolospheres derived from human induced pluripotent stem cells, here we show that cells sense multicellular-scale curvature and that it plays a role in regulating collective cell migration. As the c

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