Geometry-driven migration efficiency of autonomous epithelial cell clusters | Nature Physics

The collective migration of cell clusters is modulated by substrate geometry through a combination of velocity and polarity alignment.

Subjects Biological physics Cellular motility Abstract The directed migration of epithelial cell collectives through coordinated movements plays a crucial role in various physiological processes and is increasingly understood at the level of large confluent monolayers. However, numerous processes rely on the migration of small groups of polarized epithelial clusters in complex environments, and their responses to external geometries remain poorly understood. To address this, we cultivate primary epithelial keratocyte tissues on adhesive microstripes to create autonomous epithelial clusters wit

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