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Pulsatile contractions and pattern formation in excitable actomyosin cortex | PLOS Computational Biology

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Author summary The cellular actin cortex is a dynamic sub-membranous network of filamentous actin, myosin motors, and other accessory proteins that regulates the ability of cells to maintain or change shapes. While the key molecular components and mechanical properties of the actin cortex have been characterized, the ways in which biochemical signalling and mechanical forces interact to regulate cortex behaviours remain poorly understood. In this article, we develop a mathematical model for the actomyosin cortex that combines the reaction-diffusion dynamics of signalling proteins with active force generation by actomyosin networks. Using this model, we investigate how the feedback between mechanics and biochemical signalling regulates the propagation of actomyosin flows, mechanical stresses, and pattern formation in the cortex. Our work reveals a variety of ways in which the cortex can tune the dynamic coupling between biochemical activity, force production, and advective transport to control mechanical behaviours.

Pulsatile contractions and pattern formation in excitable actomyosin cortex | PLOS Computational Biology Article Authors Metrics Comments Media Coverage Peer Review Reader Comments Figures Figures Abstract The actin cortex is an active adaptive material, embedded with complex regulatory networks that can sense, generate, and transmit mechanical forces. The cortex exhibits a wide range of dynamic behaviours, from generating pulsatory contractions and travelling waves to forming organised structures. Despite the progress in characterising the biochemical and mechanical components of the actin co

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