Research - Martin Lab at MIT
The Martin lab is interested in how tissues get into shape. Understanding tissue shape requires understanding how cells generate force and work together to collectively sculpt a tissue. One system that a cell uses to generate force is the actin-myosin cytoskeleton; a network composed of the molecular motor myosin, which slides actin filaments together to pull on boundaries of the cell (contractile force). We have elucidated how cells generate force and how this force is propagated to the tissue-level to fold a tissue. We continue to study how tissue integrity is regulated and also investigate mechanisms that regulate the epithelial-to-mesenchymal transition or EMT and cell division orientation. We do so using fruit fly and mouse model systems. We have an ongoing collaboration with experts in physical mechanisms of pattern formation and mathematical modeling (Jörn Dunkel’s lab, Math) to learn new things and solve interdisciplinary problems. Research in the Martin Lab falls in the follow
Research – MartinLab Skip to content Introduction The Martin lab is interested in how tissues get into shape. Understanding tissue shape requires understanding how cells generate force and work together to collectively sculpt a tissue. One system that a cell uses to generate force is the actin-myosin cytoskeleton; a network composed of the molecular motor myosin, which slides actin filaments together to pull on boundaries of the cell (contractile force). We have elucidated how cells generate force and how this force is propagated to the tissue-level to fold a tissue. We continue to study
related reading
- Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding | Nature Communicationsnature.com
- Forced into shape: Mechanical forces in Drosophila development and homeostasis - PMCncbi.nlm.nih.gov
- Munro Lab – University of Chicagomunrolab.uchicago.edu
- Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton - PMCncbi.nlm.nih.gov
- Patterning and Morphogenesis From Cells to Organisms: Progress, Common Principles and New Challenges - PMCncbi.nlm.nih.gov
- Brillouin microscopy: an emerging tool for mechanobiologynature.com
- Research | Streichan Labstreichanlab.physics.ucsb.edu
- Filopodia-based contact stimulation of cell migration drives tissue morphogenesis | Nature Communicationsnature.com
- Programmed and self-organized flow of information during morphogenesis | Nature Reviews Molecular Cell Biologynature.com
- Myoblast cityen.wikipedia.org
- Pulsatile contractions and pattern formation in excitable actomyosin cortex | PLOS Computational Biologyjournals.plos.org
- organoid morphodynamics | Living Matter Labtzerhan.com