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Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding | Nature Communications

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Epithelial sheet migration proceeds via a series of actomyosin contractions, called pulses, that are stabilized, or ratcheted. Here, Xie and Martin develop a computational framework to determine how pulses are coordinated, and show that ratcheting of pulses allows collective migration by preventing competition with neighbouring pulses.

Download PDF Subjects Cell signalling Computational biophysics Contractile proteins Morphogenesis Abstract Cellular forces generated in the apical domain of epithelial cells reshape tissues. Recent studies highlighted an important role for dynamic actomyosin contractions, called pulses, that change cell and tissue shape. Net cell shape change depends on whether cell shape is stabilized, or ratcheted, between pulses. Whether there are different classes of contractile pulses in wild-type embryos and how pulses are spatiotemporally coordinated is unknown. Here we develop a computational framework

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