Lymphatic or Hematogenous Dissemination: How Does a Metastatic Tumor Cell Decide? - PMC

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. Author manuscript; available in PMC: 2006 May 11. Published in final edited form as: Cell Cycle. 2006 Apr 17;5(8):812–817. doi: 10.4161/cc.5.8.2646 Abstract The formation of distant metastases is the deadliest phase of cancer progression. Although numerous studies have identified genes and mechanisms that affect metastasis after tumors have reached secondary sites, our knowledge about how cancer cells initially gain access to systemic circulation is limited. Since tumors can enter the blood directly by intravasating into venous capillaries or indirectly via lymphatics, it is important…

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