Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer | Nature
Functional genomics and lipidomic analyses reveal that sphingolipid synthesis is required for tumour immune evasion and tumour growth in vivo, mediated in part by the impact of glycosphingolipid synthesis on cell surface expression of IFNγ receptors.
Data availability Proteomics data have been deposited to the ProteomeXchange Consortium with the dataset identifier PXD052718. scRNA-seq data has been deposited to the NCBI Gene Expression Omnibus and can be accessed with the accession number GSE270660. Source data are provided with this paper. References Ubellacker, J. M. et al. Lymph protects metastasizing melanoma cells from ferroptosis. Nature 585, 113–118 (2020). Article ADS CAS PubMed PubMed Central Google Scholar Young, R. M. et al. Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under…
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